Transcriptomics

Dataset Information

4

Host response and dysfunction in the CNS during chronic simian immunodeficiency virus infection [human study]


ABSTRACT: Finding the differences in gene expression in three regions of the brai, basal ganglia, white matter, and frontal cortex, in normal, HIV infected, HIV inefected with neurocognitive impairment, and HIV infected with both neurocognitive impairment and encephalitis patients. We used microarrays to identify differentially expressed genes in normal, HIV infected, HIV inefected with neurocognitive impairment, and HIV infected with both neurocognitive impairment and encephalitis patients. Samples from three different brain regions from normal, HIV infected, HIV infected with neurocognitive impairment (HAD: HIV-associated dementia), and HIV infected with both neurocognitive impairment and encephalitis (HIVE: HIV encephalitis) patients were collected for RNA isolation and supsequent Affymetrix microarray analysis. We sought to obtain gene expression levels in different brain regions to find implication of HIV and the neurological impairment and inflammation associated with HIV infection.

ORGANISM(S): Homo sapiens  

SUBMITTER: Jessica M Winkler   Benjamin B Gelman  Jessica Winkler 

PROVIDER: E-GEOD-35864 | ArrayExpress | 2012-07-31

SECONDARY ACCESSION(S): GSE35864PRJNA151885

REPOSITORIES: GEO, ArrayExpress

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