Transcriptomics

Dataset Information

4

MDA-MB-231 eIF4E RIP-CHIP


ABSTRACT: Cytoplasmic RNA bound to eIF4E was pulled down from MDA-MB-231 cells to determine the influence of radiation on eIF4E mRNA binding 4 samples were analyzed with 3 biological replicates

ORGANISM(S): Homo sapiens  

SUBMITTER: Uma T Shankavaram   Thomas J Hayman  Kevin Camphausen  Philip J Tofilon  Eli S Williams  Muhammad Jamal 

PROVIDER: E-GEOD-36179 | ArrayExpress | 2012-06-14

SECONDARY ACCESSION(S): GSE36179PRJNA152921

REPOSITORIES: GEO, ArrayExpress

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Publications

Translation initiation factor eIF4E is a target for tumor cell radiosensitization.

Hayman Thomas J TJ   Williams Eli S ES   Jamal Muhammad M   Shankavaram Uma T UT   Camphausen Kevin K   Tofilon Philip J PJ  

Cancer research 20120307 9


A core component in the cellular response to radiation occurs at the level of translational control of gene expression. Because a critical element in translation control is the availability of the initiation factor eIF4E, which selectively enhances the cap-dependent translation of mRNAs, we investigated a regulatory role for eIF4E in cellular radiosensitivity. eIF4E silencing enhanced the radiosensitivity of tumor cell lines but not normal cells. Similarly, pharmacologic inhibition of eIF4E with  ...[more]

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