Transcriptomics

Dataset Information

531

PAR-CLIP of RBM4 and HIF-2a


ABSTRACT: To identify which mRNAs bind to RBM4/HIF-2a Two PAR-CLIPs were performed: One of an RBM4 immunoprecipitation, and the other of a HIF-2a immunoprecipitation and excising the associated RBM4 band.

ORGANISM(S): Homo sapiens  

SUBMITTER: Josianne Payette   Jim Uniacke  Aleksandra Franovic  Gabriel Lachance  Chet E Holterman  Arnim Pause  James Uniacke  Martin Holcik  Marc R Fabian  Mathieu D Jacob  Stephen Lee 

PROVIDER: E-GEOD-36247 | ArrayExpress | 2012-05-06

SECONDARY ACCESSION(S): SRP011235GSE36247PRJNA153059

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications


Protein synthesis involves the translation of ribonucleic acid information into proteins, the building blocks of life. The initial step of protein synthesis is the binding of the eukaryotic translation initiation factor 4E (eIF4E) to the 7-methylguanosine (m(7)-GpppG) 5' cap of messenger RNAs. Low oxygen tension (hypoxia) represses cap-mediated translation by sequestering eIF4E through mammalian target of rapamycin (mTOR)-dependent mechanisms. Although the internal ribosome entry site is an alte  ...[more]

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