Transcriptomics

Dataset Information

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Gene profiling in mucosal biopsies of Eosinophilic Esophagitis patients pre and post glucocorticoid steroid treatment


ABSTRACT: Eosinophlic esophagitis (EoE) is increasely recognized as an antigen-drived disorder. The goal of this study is to reveal the gene expression changes in EoE before and after a successful glucocorticoid steroid treatment. We used microarrays to identify distinct genes involving the pathophysiology of EoE. Esophageal mRNA from the epithelial layers of 5 paired paraffin-embedded biopsies before and after treatment with glucocorticosteroids were harvested and profiled using Affymetrix Human Gene 1.0 ST array to generate differentially regulated mRNA transcripts.

ORGANISM(S): Homo sapiens  

SUBMITTER: Murray B Resnick   Shaolei Lu  Vincent A Mukkada  Kelly Cleveland  Christopher Schorl 

PROVIDER: E-GEOD-36725 | ArrayExpress | 2012-03-23

SECONDARY ACCESSION(S): GSE36725PRJNA155461

REPOSITORIES: GEO, ArrayExpress

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