Transcriptomics,Genomics

Dataset Information

60

Mutant p53 cooperates with ETS2 to promote etoposide resistance


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE36749: Mutant p53 cooperates with ETS2 to promote etoposide resistance [ChIP-Seq] GSE36751: Mutant p53 cooperates with ETS2 to promote etoposide resistance [ChIP-chip] Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Luis A Martinez  

PROVIDER: E-GEOD-36752 | ArrayExpress | 2012-05-02

SECONDARY ACCESSION(S): GSE36752PRJNA156727

REPOSITORIES: GEO, ArrayExpress

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Publications


Mutant p53 (mtp53) promotes chemotherapy resistance through multiple mechanisms, including disabling proapoptotic proteins and regulating gene expression. Comparison of genome wide analysis of mtp53 binding revealed that the ETS-binding site motif (EBS) is prevalent within predicted mtp53-binding sites. We demonstrate that mtp53 regulates gene expression through EBS in promoters and that ETS2 mediates the interaction with this motif. Importantly, we identified TDP2, a 5'-tyrosyl DNA phosphodiest  ...[more]

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