Transcriptomics,Genomics

Dataset Information

62

Identification of a FOXO3/IRF7 circuit that limits inflammatory sequelae of antiviral responses


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE36241: Identification of a FOXO3/IRF7 circuit that limits inflammatory sequelae of antiviral responses (ChIP-Seq) GSE37051: Identification of a FOXO3/IRF7 circuit that limits inflammatory sequelae of antiviral responses (expression) Refer to individual Series

ORGANISM(S): Mus musculus  

SUBMITTER: Ayush Raman  

PROVIDER: E-GEOD-37052 | ArrayExpress | 2012-09-19

SECONDARY ACCESSION(S): GSE37052PRJNA157833

REPOSITORIES: GEO, ArrayExpress

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Publications

A FOXO3-IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses.

Litvak Vladimir V   Ratushny Alexander V AV   Lampano Aaron E AE   Schmitz Frank F   Huang Albert C AC   Raman Ayush A   Rust Alistair G AG   Bergthaler Andreas A   Aitchison John D JD   Aderem Alan A  

Nature 20120916 7420


Antiviral responses must be tightly regulated to defend rapidly against infection while minimizing inflammatory damage. Type 1 interferons (IFN-I) are crucial mediators of antiviral responses and their transcription is regulated by a variety of transcription factors; principal among these is the family of interferon regulatory factors (IRFs). The IRF gene regulatory networks are complex and contain multiple feedback loops. The tools of systems biology are well suited to elucidate the complex int  ...[more]

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