Transcriptomics

Dataset Information

6

TET2 loss-of-function mutations associate with a DNA hypermethylation signature in diffuse large B-cell lymphoma


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Vasu Punj  

PROVIDER: E-GEOD-37365 | ArrayExpress | 2013-10-10

SECONDARY ACCESSION(S): GSE37365PRJNA159731

REPOSITORIES: GEO, ArrayExpress

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Publications

Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma.

Asmar Fazila F   Punj Vasu V   Christensen Jesper J   Pedersen Marianne T MT   Pedersen Anja A   Nielsen Anders B AB   Hother Christoffer C   Ralfkiaer Ulrik U   Brown Peter P   Ralfkiaer Elisabeth E   Helin Kristian K   Grønbæk Kirsten K  

Haematologica 20130705 12


The discovery that the Ten-Eleven Translocation (TET) hydroxylases cause DNA demethylation has fundamentally changed the notion of how DNA methylation is regulated. Clonal analysis of the hematopoetic stem cell compartment suggests that TET2 mutations can be early events in hematologic cancers and recent investigations have shown TET2 mutations in diffuse large B-cell lymphoma. However, the detection rates and the types of TET2 mutations vary, and the relation to global methylation patterns has  ...[more]

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