Transcriptomics

Dataset Information

65

Function, targets and evolution of Caenorhabditis elegans piRNAs


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE28617: Function, targets and evolution of Caenorhabditis elegans piRNAs (small RNA-Seq) GSE37432: Function, targets and evolution of Caenorhabditis elegans piRNAs (mRNA) Refer to individual Series

OTHER RELATED OMICS DATASETS IN: E-GEOD-37432

ORGANISM(S): Caenorhabditis elegans  

SUBMITTER: Leonard Goldstein  

PROVIDER: E-GEOD-37433 | ArrayExpress | 2012-06-17

SECONDARY ACCESSION(S): GSE37433PRJNA160127

REPOSITORIES: GEO, ArrayExpress

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Publications

Function, targets, and evolution of Caenorhabditis elegans piRNAs.

Bagijn Marloes P MP   Goldstein Leonard D LD   Sapetschnig Alexandra A   Weick Eva-Maria EM   Bouasker Samir S   Lehrbach Nicolas J NJ   Simard Martin J MJ   Miska Eric A EA  

Science (New York, N.Y.) 20120614 6094


Piwi-interacting RNAs (piRNAs) are small RNAs required to maintain germline integrity and fertility, but their mechanism of action is poorly understood. Here we demonstrate that Caenorhabditis elegans piRNAs silence transcripts in trans through imperfectly complementary sites. Target silencing is independent of Piwi endonuclease activity or "slicing." Instead, piRNAs initiate a localized secondary endogenous small interfering RNA (endo-siRNA) response. Endogenous protein-coding gene and transpos  ...[more]

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