Transcriptomics

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Cross-species transcriptional network analysis defines shared inflammatory responses in murine and human lupus nephritis [Glomeruli]


ABSTRACT: Expression data from human with IgA nephropathy (IgAN) and hypertensive nephropathy (HT) We used microarrays to analyze the transcriptome of microdissected renal biopsies from patients with IgAN and HT RNA from glomeruli and tubulointerstitial compartments was extracted and processed for hybridization on Affymetrix microarrays.

ORGANISM(S): Homo sapiens  

SUBMITTER: Celine C Berthier   Erwin P Bottinger  Weija Zhang  Matthias Kretzler  Stephan Segerer  Meera Ramanujam  Viji Nair  Tania Gonzalez-Rivera  Ramalingam Bethunaickan  Anne Davidson 

PROVIDER: E-GEOD-37460 | ArrayExpress | 2012-12-10

SECONDARY ACCESSION(S): GSE37460PRJNA160205

REPOSITORIES: GEO, ArrayExpress

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Publications

Cross-species transcriptional network analysis defines shared inflammatory responses in murine and human lupus nephritis.

Berthier Celine C CC   Bethunaickan Ramalingam R   Gonzalez-Rivera Tania T   Nair Viji V   Ramanujam Meera M   Zhang Weijia W   Bottinger Erwin P EP   Segerer Stephan S   Lindenmeyer Maja M   Cohen Clemens D CD   Davidson Anne A   Kretzler Matthias M  

Journal of immunology (Baltimore, Md. : 1950) 20120620 2


Lupus nephritis (LN) is a serious manifestation of systemic lupus erythematosus. Therapeutic studies in mouse LN models do not always predict outcomes of human therapeutic trials, raising concerns about the human relevance of these preclinical models. In this study, we used an unbiased transcriptional network approach to define, in molecular terms, similarities and differences among three lupus models and human LN. Genome-wide gene-expression networks were generated using natural language proces  ...[more]

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