Transcriptomics

Dataset Information

3

Transciptome analysis of Salmonella enterica serovar Typhimurium UK1 delta-rsiM at oxidative stress


ABSTRACT: Salmonella has various mechanisms of small RNA-mediated gene regulation. In Salmonella enterica serovar Typhimurium, a novel intergenic transcript RsiM is involved in oxidative stress response which functions as one of the powerful antimicrobials in macrophage innate immunity. We note that the ∆rsiM mutant is sensitive to hydrogen peroxide (5.0mM). This finding provides insights into the function of RsiM as a regulator of oxidative stress response. UK1 wild-type and ∆rsiM strains were grown in LB medium at 37℃ to an OD600 of 0.6, and then subjected to oxidative stress (5.0 mM hydroperoxide) for 30 min. Total RNA was extracted from three biological replicates of wild-type and ∆rsiM mutant.

ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. UK-1  

SUBMITTER: YongHeon Lee   YongKeun Park  Yong Keun Park  Sinyeon Kim 

PROVIDER: E-GEOD-37626 | ArrayExpress | 2012-06-30

SECONDARY ACCESSION(S): GSE37626PRJNA162565

REPOSITORIES: GEO, ArrayExpress

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