Genomics

Dataset Information

6

Genome binding profile of the conserved CSB-PGBD3 fusion protein in CSB-null UVSS1KO cells


ABSTRACT: The CSB-PGBD3 fusion protein arose over 43 million years ago when a 2.5 kb piggyBac 3 (PGBD3) transposon inserted into intron 5 of the Cockayne syndrome Group B (CSB) gene in the common ancestor of all higher primates. The CSB-PGBD3 fusion protein binds internally-deleted PGBD3 elements called MER85s in vitro, and induces a strong interferon-like innate antiviral immune response when expressed in CSB-null UVSS1KO cells. To explore the connection between DNA binding and gene expression changes induced by CSB-PGBD3, we investigated the genome-wide DNA binding profile of the fusion protein. 1 ChIP sample and 1 unenriched input control from the same crosslinked chromatin pool

ORGANISM(S): Homo sapiens  

SUBMITTER: Lucas Gray   Lucas T Gray  Jay Shendure  Alan M Weiner  Choli Lee 

PROVIDER: E-GEOD-37919 | ArrayExpress | 2012-07-10

SECONDARY ACCESSION(S): SRP013023GSE37919PRJNA165669

REPOSITORIES: GEO, ArrayExpress, ENA

Dataset's files

Source:
Action DRS
E-GEOD-37919.idf.txt Idf
E-GEOD-37919.processed.1.zip Processed
E-GEOD-37919.processed.2.zip Processed
E-GEOD-37919.sdrf.txt Txt
Items per page:
1 - 4 of 4
altmetric image

Publications

Tethering of the conserved piggyBac transposase fusion protein CSB-PGBD3 to chromosomal AP-1 proteins regulates expression of nearby genes in humans.

Gray Lucas T LT   Fong Kimberly K KK   Pavelitz Thomas T   Weiner Alan M AM  

PLoS genetics 20120927 9


The CSB-PGBD3 fusion protein arose more than 43 million years ago when a 2.5-kb piggyBac 3 (PGBD3) transposon inserted into intron 5 of the Cockayne syndrome Group B (CSB) gene in the common ancestor of all higher primates. As a result, full-length CSB is now coexpressed with an abundant CSB-PGBD3 fusion protein by alternative splicing of CSB exons 1-5 to the PGBD3 transposase. An internal deletion of the piggyBac transposase ORF also gave rise to 889 dispersed, 140-bp MER85 elements that were m  ...[more]

Similar Datasets

2014-02-18 | E-GEOD-44849 | ArrayExpress
2014-03-20 | E-GEOD-56049 | ArrayExpress
2014-09-22 | E-GEOD-58253 | ArrayExpress
2012-07-10 | E-GEOD-37919 | BioStudies
2015-01-01 | S-EPMC4517778 | BioStudies
2012-01-01 | S-EPMC3340519 | BioStudies
2008-01-01 | S-EPMC2268245 | BioStudies
2013-01-01 | S-EPMC3654029 | BioStudies
2012-01-01 | S-EPMC3459987 | BioStudies
2006-11-13 | E-TABM-137 | ArrayExpress