Dataset Information


Expression data comparing KYSE-140 ESCC cell line CD90+ and CD90- cells

ABSTRACT: To identify candidate genes involved in enhanced tumorigenicity and metastasis of CD90+ esophageal tumor-initiating cells. The esophageal squamous carcinoma cell (ESCC) cell line KYSE-140 was sorted into CD90+ and CD90- populations by flow cytometry. Total RNA was analyzed on Affymetrix Human Genome U133 Plus GeneChip 2.0 arrays.

ORGANISM(S): Homo sapiens  

SUBMITTER: Stephanie Ma  

PROVIDER: E-GEOD-37949 | ArrayExpress | 2013-03-23



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A CD90(+) tumor-initiating cell population with an aggressive signature and metastatic capacity in esophageal cancer.

Tang Kwan Ho KH   Dai Yong Dong YD   Tong Man M   Chan Yuen Piu YP   Kwan Pak Shing PS   Fu Li L   Qin Yan Ru YR   Tsao Sai Wah SW   Lung Hong Lok HL   Lung Maria L ML   Tong Daniel K DK   Law Simon S   Chan Kwok Wah KW   Ma Stephanie S   Guan Xin Yuan XY  

Cancer research 20130204 7

Tumor-initiating cells (TIC), also known as cancer stem cells, are regarded widely as a specific subpopulation of cells needed for cancer initiation and progression. TICs have yet to be identified in esophageal tumors that have an increasing incidence in developed countries. Here, we report a CD90(+) cell population found in esophageal squamous cell carcinoma (ESCC), which is endowed with stem cell-like properties and high tumorigenic and metastatic potential. mRNA profiling of these cells sugge  ...[more]

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