Transcriptomics

Dataset Information

20

Janus-Like Opposing Roles of CD47 in Autoimmune Brain Inflammation in Human and Mice


ABSTRACT: Gene transcripts and proteins expressed during disease pathogenesis identify targets for therapy. We performed microarray analysis of histologically characterized multiple sclerosis (MS) brain lesions in comparison with control brain samples to identify differentially expressed molecules. We identified CD47 as a target of interest and studied its biology in MS and EAE. We isolated total RNA from acute plaque (AP), chronic active plaque (CAP) and chronic plaque (CP) from MS brains and white matter from healthy controls and performed microarray studies.

ORGANISM(S): Homo sapiens  

SUBMITTER: David K Han  Mark Chao  Raymond A Sobel  Irving Weissman  Peggy P Ho  Cedric S Raine  Kareem Graham  Servio E Baranzini  Lawrence Steinman  Sara E Brownell  Jack V Hunt  Christopher B Lock  Maria Zondilova  Robert C Axtell  Siddhartha Jaiswal  Deborah H Lundgren  May H Han  Eugene Butcher  Joslyn I Woodward 

PROVIDER: E-GEOD-38010 | ArrayExpress | 2012-06-23

SECONDARY ACCESSION(S): GSE38010PRJNA167092

REPOSITORIES: GEO, ArrayExpress

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Publications

Transcriptomic meta-analysis of multiple sclerosis and its experimental models.

Raddatz Barbara B R BB   Hansmann Florian F   Spitzbarth Ingo I   Kalkuhl Arno A   Deschl Ulrich U   Baumgärtner Wolfgang W   Ulrich Reiner R  

PloS one 20140127 1


BACKGROUND: Multiple microarray analyses of multiple sclerosis (MS) and its experimental models have been published in the last years. OBJECTIVE: Meta-analyses integrate the information from multiple studies and are suggested to be a powerful approach in detecting highly relevant and commonly affected pathways. DATA SOURCES: ArrayExpress, Gene Expression Omnibus and PubMed databases were screened for microarray gene expression profiling studies of MS and its experimental animal models. STUDY ELI  ...[more]

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