Genomics

Dataset Information

8

Genome-wide maps of nucleosome positions in Saccharomyces strains bearing heterologous DNA on yeast artificial chromosomes


ABSTRACT: We identify the cis and trans determinants of nucleosome positioning using a functional evolutionary approach involving S. cerevisiae strains containing large genomic regions from other yeast species. In a foreign species, nucleosome depletion at promoters is maintained over poly(dA:dT) tracts, whereas internucleosome spacing and all other aspects of nucleosome positioning tested are not. Interestingly, the locations of the +1 nucleosome and RNA start sites shift in concert. Strikingly, in a foreign species, nucleosome-depleted regions occur fortuitously in coding regions, and they often act as promoters that are associated with a positioned nucleosome array linked to the length of the transcription unit. nucleosome mapping for 3 strains bearing yeast artificial chromosomes from Kluyveromyces lactis and 2 strains with Debaryomyces hansenii artificial chromosomes in Saccharomyces cerevisiae

ORGANISM(S): Saccharomyces cerevisiae  

SUBMITTER: Kevin Struhl   Amanda Hughes  Yi Jin  Oliver J Rando 

PROVIDER: E-GEOD-39011 | ArrayExpress | 2012-06-30

SECONDARY ACCESSION(S): GSE39011SRP014001PRJNA169603

REPOSITORIES: GEO, ArrayExpress, ENA

Dataset's files

Source:
Action DRS
E-GEOD-39011.README.txt Txt
E-GEOD-39011.idf.txt Idf
E-GEOD-39011.processed.1.zip Processed
E-GEOD-39011.sdrf.txt Txt
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