Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Mark B Meyer J W Pike
PROVIDER: E-GEOD-39277 | ArrayExpress | 2012-09-05
SECONDARY ACCESSION(S): SRP014204GSE39277PRJNA170469
REPOSITORIES: GEO, ArrayExpress, ENA
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Meyer Mark B MB Pike J Wesley JW
The Journal of steroid biochemistry and molecular biology 20120825
Transcription factors require coactivators and corepressors to modulate transcription in mammalian cells. The vitamin D receptor (VDR) utilizes coactivators and corepressors to gain tight control over the activity of a diverse set of genes that can regulate calcium transport, slow proliferation and promote immune responses. We have recently established the VDR/RXR cistrome in human colon cancer cells and have linked these binding sites to the genes that are regulated by 1α,25-dihydroxyvitamin D3 ...[more]