Transcriptomics

Dataset Information

6

MicroRNA-138: A Pro-survival OncomiR for Glioma Stem Cells is Associated with Tumor Recurrence [miRNA]


ABSTRACT: We report the identification of microRNA-138 (miR-138), as a molecular signature of GSCs and demonstrate a vital role for miR-138 to promote growth and survival of bona fide tumor-initiating cells with self-renewal potential. Total RNA from Glioma Stem Cells and Neural Stem Cells were subjected to microRNA microarray analysis, 3 replicates each.

ORGANISM(S): Homo sapiens  

SUBMITTER: Srikanth Nama   Prabha Sampath 

PROVIDER: E-GEOD-39486 | ArrayExpress | 2012-12-20

SECONDARY ACCESSION(S): GSE39486PRJNA170985

REPOSITORIES: GEO, ArrayExpress

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Publications


Malignant gliomas are the most aggressive forms of brain tumors, associated with high rates of morbidity and mortality. Recurrence and tumorigenesis are attributed to a subpopulation of tumor-initiating glioma stem cells (GSCs) that are intrinsically resistant to therapy. Initiation and progression of gliomas have been linked to alterations in microRNA expression. Here, we report the identification of microRNA-138 (miR-138) as a molecular signature of GSCs and demonstrate a vital role for miR-13  ...[more]

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