Genomics

Dataset Information

4

Expression data from early B cell progenitors including CLP,ProB and PreB of Pax5 knockout and wild type C57Bl6 mice


ABSTRACT: we have investigated molecular and functional properties in early B-lineage cells from Pax-5 deficient animals crossed to a B-lineage restricted reporter mouse. Gene expression analysis of ex vivo isolated progenitor cells revealed that Pax-5 deficiency has a minor impact on Bcell specification.By comparison of gene expression patterns in ex vivo isolated Pax-5 and Ebf-1 deficient progenitors, it was possible to identify a set of B-cell restricted genes dependent of Ebf-1 but not Pax-5, supporting the idea that B-cell specification and commitment is controlled by distinct regulatory networks. wt λ5 reporter+ and Pax5ko λ5reporter+ fetal liver from d15 embryos isolated and transplanted into sublethaly irradiated mice. After 4 weeks B220+λ5+ cells were sorted out from the bone marrow of the mice and subjected to microarray analyses

ORGANISM(S): Mus musculus  

SUBMITTER: Panagiotis Tsapogas   Josefine Åhsberg  Jenny Stjernberg  Sasan Zandi  Hong Qian  Mikael Sigvardsson 

PROVIDER: E-GEOD-39554 | ArrayExpress | 2012-07-22

SECONDARY ACCESSION(S): GSE39554PRJNA171116

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-39554.README.txt Txt
E-GEOD-39554.eSet.r Other
E-GEOD-39554.idf.txt Idf
E-GEOD-39554.processed.1.zip Processed
E-GEOD-39554.raw.1.zip Raw
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