Transcriptomics

Dataset Information

4

Gene expression profile in CD11c+ splenic dendritic cells and CD11c+CD103+ dendritic cells from mesenteric lymph nodes (MLN) of mice with DC-specific targeting of TGFBR2


ABSTRACT: Transcriptome analysis of dentritic cells from the spleen (CD11c+) or MLN (CD11c+CD103+) of mice with DC-specific deletion of TGFBR2 gene, or their control littermates. TRGFR2 gene was deleted in dendritic cells using Cre/lox approach. Mice with this deletion develop spontaneous multi-organ autoimmune inflammation and die by 15 weeks of age. Splenic CD11c+ Dc were isolated by magetic cell sorting. MLN CD11c+CD103+ DC were flow sorted. RNA was isolated using RNAqueous-Micro kit (Ambion) and analyzed using Affymetrix Mouse Exon 1.0 ST Array

ORGANISM(S): Mus musculus  

SUBMITTER: Pawel R Kiela   Fayez K Ghishan  Pawel R. Kiela  Robert D Thurston  Rajalakshmy Ramlingam  Monica T Midura-Kiela  Song-Guo Zheng  Claire B Larmonier 

PROVIDER: E-GEOD-39651 | ArrayExpress | 2012-07-25

SECONDARY ACCESSION(S): GSE39651PRJNA171331

REPOSITORIES: GEO, ArrayExpress

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