Transcriptomics

Dataset Information

3

Transcriptome analysis of ire1 mutants after treatment with or without tunicamycin in the presence of actinomycin D


ABSTRACT: Arabidopsis seedlings of wildtype or ire1a ire1b double mutant were treated with or without tunicamycine in the presence of actinomycin D (ActD). 12 samples

REANALYSED by: E-GEOD-39690

ORGANISM(S): Arabidopsis thaliana  

SUBMITTER: Yukihisa Shimada   Nozomu Koizumi 

PROVIDER: E-GEOD-39690 | ArrayExpress | 2013-03-19

SECONDARY ACCESSION(S): GSE39690PRJNA171484

REPOSITORIES: GEO, ArrayExpress

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Publications

Defects in IRE1 enhance cell death and fail to degrade mRNAs encoding secretory pathway proteins in the Arabidopsis unfolded protein response.

Mishiba Kei-ichiro K   Nagashima Yukihiro Y   Suzuki Eiji E   Hayashi Noriko N   Ogata Yoshiyuki Y   Shimada Yukihisa Y   Koizumi Nozomu N  

Proceedings of the National Academy of Sciences of the United States of America 20130318 14


The unfolded protein response (UPR) is a cellular response highly conserved in eukaryotes to obviate accumulation of misfolded proteins in the endoplasmic reticulum (ER). Inositol-requiring enzyme 1 (IRE1) catalyzes the cytoplasmic splicing of mRNA encoding bZIP transcription factors to activate the UPR signaling pathway. Arabidopsis IRE1 was recently shown to be involved in the cytoplasmic splicing of bZIP60 mRNA. In the present study, we demonstrated that an Arabidopsis mutant with defects in  ...[more]

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