Transcriptomics,Genomics

Dataset Information

125

Comparison of DNA methylation in human tissues


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Diane Irene Schroeder  

PROVIDER: E-GEOD-39777 | ArrayExpress | 2013-03-28

SECONDARY ACCESSION(S): GSE39777PRJNA171701

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications

The human placenta methylome.

Schroeder Diane I DI   Blair John D JD   Lott Paul P   Yu Hung On Ken HO   Hong Danna D   Crary Florence F   Ashwood Paul P   Walker Cheryl C   Korf Ian I   Robinson Wendy P WP   LaSalle Janine M JM  

Proceedings of the National Academy of Sciences of the United States of America 20130325 15


Tissue-specific DNA methylation is found at promoters, enhancers, and CpG islands but also over larger genomic regions. In most human tissues, the vast majority of the genome is highly methylated (>70%). Recently, sequencing of bisulfite-treated DNA (MethylC-seq) has revealed large partially methylated domains (PMDs) in some human cell lines. PMDs cover up to 40% of the genome and are associated with gene repression and inactive chromatin marks. However, to date, only cultured cells and cancers  ...[more]

Similar Datasets

2013-03-28 | E-GEOD-39775 | ArrayExpress
2015-08-05 | E-GEOD-63330 | ArrayExpress
2012-03-27 | E-GEOD-32268 | ArrayExpress
2011-06-23 | E-GEOD-25930 | ArrayExpress
2015-08-01 | E-GEOD-69836 | ArrayExpress
2013-10-09 | E-GEOD-40955 | ArrayExpress
2014-07-01 | E-GEOD-43094 | ArrayExpress
2016-08-08 | E-GEOD-62629 | ArrayExpress
2013-12-10 | E-GEOD-53025 | ArrayExpress
2014-06-04 | E-GEOD-44038 | ArrayExpress