Dataset Information


Comparison of DNA methylation in human tissues

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens  

SUBMITTER: Diane Irene Schroeder  

PROVIDER: E-GEOD-39777 | ArrayExpress | 2013-03-28



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The human placenta methylome.

Schroeder Diane I DI   Blair John D JD   Lott Paul P   Yu Hung On Ken HO   Hong Danna D   Crary Florence F   Ashwood Paul P   Walker Cheryl C   Korf Ian I   Robinson Wendy P WP   LaSalle Janine M JM  

Proceedings of the National Academy of Sciences of the United States of America 20130325 15

Tissue-specific DNA methylation is found at promoters, enhancers, and CpG islands but also over larger genomic regions. In most human tissues, the vast majority of the genome is highly methylated (>70%). Recently, sequencing of bisulfite-treated DNA (MethylC-seq) has revealed large partially methylated domains (PMDs) in some human cell lines. PMDs cover up to 40% of the genome and are associated with gene repression and inactive chromatin marks. However, to date, only cultured cells and cancers  ...[more]

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