Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA171767
ORGANISM(S): Mus Musculus
SUBMITTER: Youjin Lee Raymond A Sobel Amit Awasthi David A Hafler Nir Yosef Anneli Peters Markus Kleinewietfeld Chuan Wu Francisco J Quintana Vijay K Kuchroo Sharon Kunder
PROVIDER: E-GEOD-39820 | ArrayExpress | 2012-09-01
SECONDARY ACCESSION(S): GSE39820PRJNA171767
REPOSITORIES: GEO, ArrayExpress
Action | DRS | |||
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E-GEOD-39820.README.txt | Txt | |||
E-GEOD-39820.eSet.r | Other | |||
E-GEOD-39820.idf.txt | Idf | |||
E-GEOD-39820.processed.1.zip | Processed | |||
E-GEOD-39820.raw.1.zip | Raw |
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Lee Youjin Y Awasthi Amit A Yosef Nir N Quintana Francisco J FJ Xiao Sheng S Peters Anneli A Wu Chuan C Kleinewietfeld Markus M Kunder Sharon S Hafler David A DA Sobel Raymond A RA Regev Aviv A Kuchroo Vijay K VK
Nature immunology 20120909 10
Interleukin 17 (IL-17)-producing helper T cells (T(H)17 cells) are often present at the sites of tissue inflammation in autoimmune diseases, which has led to the conclusion that T(H)17 cells are main drivers of autoimmune tissue injury. However, not all T(H)17 cells are pathogenic; in fact, T(H)17 cells generated with transforming growth factor-β1 (TGF-β1) and IL-6 produce IL-17 but do not readily induce autoimmune disease without further exposure to IL-23. Here we found that the production of T ...[more]