Transcriptomics,Multiomics

Dataset Information

19

Induction and molecular signature of pathogenic Th17 cells


ABSTRACT: TGF-beta3 produced by developing Th17 cells induces highly pathogenic T cells that are functionally and molecularly distinct from TGF-beta1-induced Th17 cells. The microarray data represent a distinct molecular signature for pathogenic versus non-pathogenic Th17 cells. Total of seven groups with two to four samples per group from two independent experiments. The no cytokines group (Th0) was used as a control to normalize the data. 7 groups: B6: (IL-1beta, IL-6) B623: (IL-1beta, IL-6, IL-23) T16: (TGF-beta1, IL-6) T1623: (TGF-beta1, IL-6, IL-23) T36: (TGF-beta3, IL-6) T3623: (TGF-beta3, IL-6, IL-23) NOCYTO: no cytokines

OTHER RELATED OMICS DATASETS IN: PRJNA171767

ORGANISM(S): Mus Musculus

SUBMITTER: Youjin Lee   Raymond A Sobel  Amit Awasthi  David A Hafler  Nir Yosef  Anneli Peters  Markus Kleinewietfeld  Chuan Wu  Francisco J Quintana  Vijay K Kuchroo  Sharon Kunder 

PROVIDER: E-GEOD-39820 | ArrayExpress | 2012-09-01

SECONDARY ACCESSION(S): GSE39820PRJNA171767

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-39820.README.txt Txt
E-GEOD-39820.eSet.r Other
E-GEOD-39820.idf.txt Idf
E-GEOD-39820.processed.1.zip Processed
E-GEOD-39820.raw.1.zip Raw
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Publications


Interleukin 17 (IL-17)-producing helper T cells (T(H)17 cells) are often present at the sites of tissue inflammation in autoimmune diseases, which has led to the conclusion that T(H)17 cells are main drivers of autoimmune tissue injury. However, not all T(H)17 cells are pathogenic; in fact, T(H)17 cells generated with transforming growth factor-β1 (TGF-β1) and IL-6 produce IL-17 but do not readily induce autoimmune disease without further exposure to IL-23. Here we found that the production of T  ...[more]

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