Transcriptomics

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Gene expression profiling in B lymphocytes from transplanted patients


ABSTRACT: The achievement of a drug-free operational tolerance for renal transplanted patients is a major goal in organ transplantation. Previous gene expression profiling in peripheral blood mononuclear cells (PBMC) identified genes associated with operational tolerance. The identification of a common pattern of B cell-related genes associated with tolerance encourage us to analyze gene expression in purified B cell from operationally tolerant patients (TOL=10) compared to renal transplanted patients with stable graft function (STA=12) under immunosuppression and also compared to healthy volunteers (HV=10) who have no immunosuppressive treatment and no graft. Microarray analyses exhibited an absence of gene signature associated with tolerance in purified B cell compared to STA or HV. These results suggest that the B cell signatures observed in PBMC may be due to an increase number of total B cells rather than specific B cell characteristics in operationally tolerant patients. This dataset represents gene expression profiling of purified B cells from 10 renal transplanted patients with operational tolerance (TOL), 12 renal transplanted patients with stable graft function under immunosuppression (STA) and 10 healthy volunteers (HV).

ORGANISM(S): Homo sapiens  

SUBMITTER: Mélanie Chesneau   Sophie Brouard  Richard Danger 

PROVIDER: E-GEOD-39899 | ArrayExpress | 2015-08-01

SECONDARY ACCESSION(S): GSE39899PRJNA172004

REPOSITORIES: GEO, ArrayExpress

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