Transcriptomics

Dataset Information

3

MicroRNA profiling of human monocytes and monocyte-derived macrophages


ABSTRACT: microRNA profiling data includes biological replicates of primary monocytes and macrophages from three human donors Dye swap hybridization arrays were performed for total RNA isolated from fresh monocytes and 7-day monocyte-derived macrophages from each of three human donors

ORGANISM(S): Homo sapiens  

SUBMITTER: Jeanne M Sisk   Janice E Clements  Kenneth W Witwer 

PROVIDER: E-GEOD-39905 | ArrayExpress | 2013-05-10

SECONDARY ACCESSION(S): GSE39905PRJNA172008

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications

miRNA profiles of monocyte-lineage cells are consistent with complicated roles in HIV-1 restriction.

Sisk Jeanne M JM   Clements Janice E JE   Witwer Kenneth W KW  

Viruses 20120925 10


Long-lived HIV-1 reservoirs include tissue macrophages. Monocyte-derived macrophages are more susceptible to infection and more permissive to HIV-1 replication than monocytes for reasons that may include the effects of different populations of miRNAs in these two cell classes. Specifically, miRs-28-3p, -150, -223, -198, and -382 exert direct or indirect negative effects on HIV-1 and are reportedly downmodulated during monocyte-to-macrophage differentiation. Here, new experimental results are pre  ...[more]

Similar Datasets

2012-12-07 | E-GEOD-27658 | ArrayExpress
2011-07-24 | E-GEOD-30811 | ArrayExpress
2008-10-25 | E-GEOD-12259 | ArrayExpress
2016-10-03 | E-MTAB-4883 | ArrayExpress
2008-06-15 | E-GEOD-7138 | ArrayExpress
2007-10-26 | E-GEOD-5220 | ArrayExpress
2016-09-06 | E-GEOD-73765 | ArrayExpress
2009-11-03 | E-MEXP-2038 | ArrayExpress
2011-05-14 | E-GEOD-29286 | ArrayExpress
2013-03-15 | E-GEOD-36537 | ArrayExpress