Dataset Information


MicroRNA profiling of human monocytes and monocyte-derived macrophages

ABSTRACT: microRNA profiling data includes biological replicates of primary monocytes and macrophages from three human donors Dye swap hybridization arrays were performed for total RNA isolated from fresh monocytes and 7-day monocyte-derived macrophages from each of three human donors

ORGANISM(S): Homo sapiens  

SUBMITTER: Jeanne M Sisk   Janice E Clements  Kenneth W Witwer 

PROVIDER: E-GEOD-39905 | ArrayExpress | 2013-05-10



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miRNA profiles of monocyte-lineage cells are consistent with complicated roles in HIV-1 restriction.

Sisk Jeanne M JM   Clements Janice E JE   Witwer Kenneth W KW  

Viruses 20120925 10

Long-lived HIV-1 reservoirs include tissue macrophages. Monocyte-derived macrophages are more susceptible to infection and more permissive to HIV-1 replication than monocytes for reasons that may include the effects of different populations of miRNAs in these two cell classes. Specifically, miRs-28-3p, -150, -223, -198, and -382 exert direct or indirect negative effects on HIV-1 and are reportedly downmodulated during monocyte-to-macrophage differentiation. Here, new experimental results are pre  ...[more]

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