Transcriptomics

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Constitutional Trisomy 8 Mosaicism as a Model for Epigenetic Studies of Aneuploidy (DNA methylation)


ABSTRACT: To increase our understanding of epigenetic patterns associated with aneuploidy we used constitutional trisomy 8 mosaicism as a model, enabling analyses of single cell clones, harboring either trisomy or disomy 8, from the same patient. We profiled gene and miRNA expression as well as genome-wide and promoter specific DNA methylation and hydroxymethylation patterns in trisomic and disomic fibroblasts, using microarrays and methylated DNA immunoprecipitation. comparison of trisomy 8 cells with disomic as well as reference fibroblasts

ORGANISM(S): Homo sapiens  

SUBMITTER: Bertil Johansson  Josef Davidsson    

PROVIDER: E-GEOD-40317 | ArrayExpress | 2012-12-01

SECONDARY ACCESSION(S): GSE40317PRJNA173493

REPOSITORIES: GEO, ArrayExpress

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