Transcriptomics

Dataset Information

17

Transcriptional analysis of PBMCs reveals sex specific changes in the aging of the immune system


ABSTRACT: Aging and sex have a strong influence on the functional capacity of the immune system. In general, the immune response in females is stronger than that in males, but there is little information about the effect of aging on this difference. To address this question, we performed a transcriptomic analysis of peripheral blood mononuclear cells derived from nonagenarians and young controls. We found 337 and 269 genes to be differentially expressed (p<0.05, fold change >1.5 or <-1.5) in nonagenarian females and males, respectively; 177 of these were changed in both sexes. An analysis of the affected signaling pathways revealed a clear sex bias: the number of significantly changed pathways was 43 in females and 40 in males; 23 were shared. These data show that the effects of aging on the immune system are significantly different in males and females. Our study population consisted of 146 nonagenarians (103 females, 43 males) and 30 young controls (19-30 years of age, 21 females, 9 males). In our study, we analyzed the gene expression difference between nonagenarian and control women as well as between nonagenarian and control males and then compared these results.

ORGANISM(S): Homo sapiens  

SUBMITTER: Pärt Peterson   Saara Marttila  Liina Tserel  Tapio Nevalainen  Antti Hervonen  Juulia Jylhävä  Marja Jylhä  Mikko Hurme  Taru Kuparinen 

PROVIDER: E-GEOD-40366 | ArrayExpress | 2013-01-10

SECONDARY ACCESSION(S): GSE40366PRJNA173882PRJNA273430

REPOSITORIES: GEO, ArrayExpress

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Publications

Cytomegalovirus (CMV)-dependent and -independent changes in the aging of the human immune system: a transcriptomic analysis.

Kuparinen Taru T   Marttila Saara S   Jylhävä Juulia J   Tserel Liina L   Peterson Pärt P   Jylhä Marja M   Hervonen Antti A   Hurme Mikko M  

Experimental gerontology 20130102 3


Aging is associated with a profound reduction of the immune capacity (i.e., immunosenescence), which is manifested as increased morbidity and mortality due to infectious diseases in the elderly. The association of cytomegalovirus (CMV) with several aging-associated phenomena has been extensively characterized, e.g., the accumulation of CD8+ nonproliferative, apoptosis-resistant memory cells that have lost the expression of the costimulatory molecule CD28. However, as the CMV seroprevalence is no  ...[more]

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