Transcriptomics

Dataset Information

35

Chemopreventive effect of flaxseed-enriched diet on ovarian cancer in laying hen.


ABSTRACT: The objective of this study was to identify the molecular mechanisms and biological pathways associated with the anticancer effects of flaxseed (richest plant source of Omega-3 fatty acid) in laying hen model of ovarian cancer. Study shows a significant reduction in the severity of the disease and increased survival of the laying hens fed with flaxseed. 2 X 2 condition experiment, Diet (Control & Flaxseed fed) and Tissue (Normal & Cancer). Biological replicates: 6 control normal replicates, 6 control cancer replicates, 6 flaxseed normal replicates and 6 flaxseed cancer replicates.

ORGANISM(S): Gallus gallus  

SUBMITTER: Yan Zhuge  Nawneet K Kurrey   Dale B Hales   Dale Buchanan Hales   Karen H Hales    

PROVIDER: E-GEOD-40376 | ArrayExpress | 2015-05-24

SECONDARY ACCESSION(S): GSE40376PRJNA174037

REPOSITORIES: GEO, ArrayExpress

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Publications

Uncovering molecular events associated with the chemosuppressive effects of flaxseed: a microarray analysis of the laying hen model of ovarian cancer.

Hales Karen H KH   Speckman Sheree C SC   Kurrey Nawneet K NK   Hales Dale B DB  

BMC genomics 20140824


The laying hen model of spontaneous epithelial ovarian cancer (EOC) is unique in that it is the only model that enables observations of early events in disease progression and is therefore also uniquely suited for chemoprevention trials. Previous studies on the effect of dietary flaxseed in laying hens have revealed the potential for both amelioration and prevention of ovarian cancer. The objective of this study was to assess the effect of flaxseed on genes and pathways that are dysregulated in  ...[more]

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