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Characterizing the molecular spatial and temporal field of injury in early stage smoker non-small cell lung cancer patients after definitive surgery by expression profiling

ABSTRACT: Gene expression alterations in response to cigarette smoke have been characterized in normal-appearing bronchial epithelium of healthy smokers and it has been suggested that adjacent histologically normal tissue display tumor-associated molecular abnormalities. We sought to delineate the spatial and temporal molecular lung field of injury in smoker early stage non-small cell lung cancer (NSCLC) patients (n=19) who were accrued into a surveillance clinical trial for annual follow-up and bronchoscopies within one year after definitive surgery. Bronchial brushings and biopsies were obtained from six different sites in the lung at the time of inclusion in the study and at 12, 24 and 36 months after the first time point. Affymetrix Human Gene 1.0 ST arrays were used for whole-transcript expression profiling of airways (n=391). Mixed-effects models were performed to determine significant differential gene expression modulation by site from tumor and time following inclusion in the study within the molecular field of injury.

ORGANISM(S): Homo sapiens  

SUBMITTER: Ignacio I Wistuba  Humam Kadara    

PROVIDER: E-GEOD-40407 | ArrayExpress | 2015-08-19



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