Transcriptomics

Dataset Information

8

Gene expression in CF-vs-non CF human airway epithelial cell samples obtained by nasal brushing.


ABSTRACT: A small-scale whole genome microarray study of gene expression in human native nasal epithelial cells from F508del-CFTR homozygous CF patients and non-CF controls. We used the custom designed Affymetrix HsAirwaya520108F Arrays to compare gene expression in 5 CF and 5 non CF nasal epithelial cell samples. We analysed a total of 10 samples (5 CF and 5 non CF). The CF group contained 2 males and 3 females, with an average age of 14 years and an average of 6% inflammatory cells per sample, and the non CF group contained 3 males and 2 females with an average age of 14.8 years and an average of 4.7% inflammatory cells.

ORGANISM(S): Homo sapiens  

SUBMITTER: Lisete Sousa   Luka A Clarke  Luka Clarke  Margarida D Amaral 

PROVIDER: E-GEOD-40445 | ArrayExpress | 2013-04-10

SECONDARY ACCESSION(S): GSE40445PRJNA174071

REPOSITORIES: GEO, ArrayExpress

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Publications

Changes in transcriptome of native nasal epithelium expressing F508del-CFTR and intersecting data from comparable studies.

Clarke Luka A LA   Sousa Lisete L   Barreto Celeste C   Amaral Margarida D MD  

Respiratory research 20130328


BACKGROUND: Microarray studies related to cystic fibrosis (CF) airway gene expression have gone some way in clarifying the complex molecular background of CF lung diseases, but have made little progress in defining a robust "molecular signature" associated with mutant CFTR expression. Disparate methodological and statistical analyses complicate comparisons between independent studies of the CF transcriptome, and although each study may be valid in isolation, the conclusions reached differ widely  ...[more]

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