Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA174603
ORGANISM(S): Mus musculus
SUBMITTER: Richard Jenner Graham Lord M R Gökmen Aditi Kanhere
PROVIDER: E-GEOD-40623 | ArrayExpress | 2013-12-03
SECONDARY ACCESSION(S): GSE40623SRP015481PRJNA174603
REPOSITORIES: GEO, ArrayExpress, ENA
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E-GEOD-40623.idf.txt | Idf | |||
E-GEOD-40623.processed.1.zip | Processed | |||
E-GEOD-40623.processed.2.zip | Processed | |||
E-GEOD-40623.processed.3.zip | Processed | |||
E-GEOD-40623.processed.4.zip | Processed |
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Journal of immunology (Baltimore, Md. : 1950) 20131118 12
The complex relationship between Th1 and Th17 cells is incompletely understood. The transcription factor T-bet is best known as the master regulator of Th1 lineage commitment. However, attention is now focused on the repression of alternate T cell subsets mediated by T-bet, particularly the Th17 lineage. It has recently been suggested that pathogenic Th17 cells express T-bet and are dependent on IL-23. However, T-bet has previously been shown to be a negative regulator of Th17 cells. We have tak ...[more]