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Transcriptomic analyses of Myc-induced zebrafish liver cancer

ABSTRACT: To study the characteristics and mechanisms of Myc-induced zebrafish liver tumor, next-generation sequencing-based SAGE analyses were used to examine the transcriptomes of tumor and control samples. The results indicated that ribosome proteins were overwhelmingly up-regulated in the Myc-induced liver tumors. Cross-species analyses showed that the zebrafish Myc model correlated well with Myc transgenic mouse models for liver cancers. The Myc-induced zebrafish liver tumors also possessed molecular signatures highly similar to human hepatocellular carcinoma (HCC). Thus, our zebrafish model demonstrated the conserved role of Myc in promoting hepatocarcinogenesis in all vertebrate species. Transcriptome profiling of tumor samples (M+D+) and control samples (M-D-, M+D-, M-D+) were generated by deep sequencing, each in duplicates, using 3' RNA-SAGE on the SOLiD system.

ORGANISM(S): Danio rerio  

SUBMITTER: Zhiyuan Gong   Weiling Zheng  Zhen Li 

PROVIDER: E-GEOD-40745 | ArrayExpress | 2013-04-02



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A transgenic zebrafish liver tumor model with inducible Myc expression reveals conserved Myc signatures with mammalian liver tumors.

Li Zhen Z   Zheng Weiling W   Wang Zhengyuan Z   Zeng Zhiqiang Z   Zhan Huiqing H   Li Caixia C   Zhou Li L   Yan Chuan C   Spitsbergen Jan M JM   Gong Zhiyuan Z  

Disease models & mechanisms 20121004 2

Myc is a pleiotropic transcription factor that is involved in many cellular activities relevant to carcinogenesis, including hepatocarcinogenesis. The zebrafish has been increasingly used to model human diseases and it is particularly valuable in helping to identify common and conserved molecular mechanisms in vertebrates. Here we generated a liver tumor model in transgenic zebrafish by liver-specific expression of mouse Myc using a Tet-On system. Dosage-dependent induction of Myc expression spe  ...[more]

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