Transcriptomics,Multiomics

Dataset Information

40

Expression data from hiPSCs-NSCs towards 4T1


ABSTRACT: Neural stem cells can migrate towards tumors of both neural and non-neural origins, which is crucial for the success in treating disseminated tumors. Although the understanding of the molecular mechanisms underlying NSC tumor tropism is limited, it has been noted that several cytokines, growth factors and receptors direct the migration in vitro. A proper understanding of the basic molecular mechanisms of NSC migration towards tumors, especially identification of key cellular regulators of the migration, will have important implications in improving the effectiveness of engineering and employing NSCs as tumor therapy agents. We compared gene expression profiles between migratory and non-migratory hiPSC-NSCs towards cancer cells using cDNA microarray profiling. We collected human iPSCs derived NSCs migrating and not migrating towards mouse 4T1 breast cancer cells in an in vitro migration system for total RNA extraction and hybridization to Affymetrix microarrays

REANALYSED by: E-GEOD-40750

ORGANISM(S): Homo sapiens  

SUBMITTER: Can Chen   

PROVIDER: E-GEOD-40750 | ArrayExpress | 2015-08-19

SECONDARY ACCESSION(S): GSE40750PRJNA174809

REPOSITORIES: GEO, ArrayExpress

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Publications

Inhibition of neuronal nitric oxide synthase activity promotes migration of human-induced pluripotent stem cell-derived neural stem cells toward cancer cells.

Chen Can C   Wang Yi Y   Goh Sally S L SS   Yang Jing J   Lam Dang Hoang DH   Choudhury Yukti Y   Tay Felix Chang FC   Du Shouhui S   Tan Wee Kiat WK   Purwanti Yovita Ida YI   Fan Weimin W   Wang Shu S  

Journal of neurochemistry 20130317 3


The breakthrough in derivation of human-induced pluripotent stem cells (hiPSCs) provides an approach that may help overcome ethical and allergenic challenges posed in numerous medical applications involving human cells, including neural stem/progenitor cells (NSCs). Considering the great potential of NSCs in targeted cancer gene therapy, we investigated in this study the tumor tropism of hiPSC-derived NSCs and attempted to enhance the tropism by manipulation of biological activities of proteins  ...[more]

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