Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Elissa P Lei Leah H Matzat Ryan K Dale Ryan Dale
PROVIDER: E-GEOD-40797 | ArrayExpress | 2012-11-30
SECONDARY ACCESSION(S): SRP015720GSE40797PRJNA175001
REPOSITORIES: GEO, ArrayExpress, ENA
Matzat Leah H LH Dale Ryan K RK Moshkovich Nellie N Lei Elissa P EP
PLoS genetics 20121129 11
Chromatin insulators organize the genome into distinct transcriptional domains and contribute to cell type-specific chromatin organization. However, factors regulating tissue-specific insulator function have not yet been discovered. Here we identify the RNA recognition motif-containing protein Shep as a direct interactor of two individual components of the gypsy insulator complex in Drosophila. Mutation of shep improves gypsy-dependent enhancer blocking, indicating a role as a negative regulator ...[more]