Transcriptomics

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SM019 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1b knockout mice


ABSTRACT: Comparing the host response of C57BL/6J mice to Tnfrsf1b knockouts in the same strain of mice. Groups of 10-week-old C57BL/6 mice or Tnfrsf1a/1b knockout mice were infected with SARS MA15 at a dose of 10^5 PFU or mock infected. Mice were euthanized on days 4 and 7 post-infection to measure virus load and isolate samples for measurement of virus load, lung pathology, transcriptional analysis and proteomics analysis. Mock-infected animals were also harvested at each time point. Mice were weighed every 24 hours to measure general disease progression and any mouse approaching 30% weight loss was euthanized.

ORGANISM(S): Mus musculus  

SUBMITTER: Lynn Law  Ralph Baric   Jean Chang   Richard Roy Green   Michael Katze   Lisa Gralinski    

PROVIDER: E-GEOD-40824 | ArrayExpress | 2012-09-13

SECONDARY ACCESSION(S): GSE40824PRJNA175045

REPOSITORIES: GEO, ArrayExpress

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