Transcriptomics

Dataset Information

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Expression data from wild type and deltaS4473 Shigella flexneri 2457T


ABSTRACT: Comparison of wild type S. flexneri 2457T gene expression to deletion mutant of S. flexneri 2457T gene S4473 at three growth phases and intracellularly Broth culture was grown to mid-log in LB, intracellular growth was 3 hours post invasion of HCT-8 cell (colonic epithelial cell line).

ORGANISM(S): Shigella flexneri 2a str. 2457T  

SUBMITTER: David A Rasko   Eileen Barry  David Rasko  Carolyn Morris 

PROVIDER: E-GEOD-40851 | ArrayExpress | 2013-10-18

SECONDARY ACCESSION(S): GSE40851PRJNA175114

REPOSITORIES: GEO, ArrayExpress

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Publications

Characterization of intracellular growth regulator icgR by utilizing transcriptomics to identify mediators of pathogenesis in Shigella flexneri.

Morris Carolyn R CR   Grassel Christen L CL   Redman Julia C JC   Sahl Jason W JW   Barry Eileen M EM   Rasko David A DA  

Infection and immunity 20130610 9


Shigella species Gram-negative bacteria which cause a diarrheal disease, known as shigellosis, by invading and destroying the colonic mucosa and inducing a robust inflammatory response. With no vaccine available, shigellosis annually kills over 600,000 children in developing countries. This study demonstrates the utility of combining high-throughput bioinformatic methods with in vitro and in vivo assays to provide new insights into pathogenesis. Comparisons of in vivo and in vitro gene expressio  ...[more]

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