Dataset Information


The Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer

ABSTRACT: Poor outcomes in diabetic patients are observed across a range of human tumors, suggesting that cancer cells develop unique characteristics under diabetic conditions. Cancer cells exposed to hyperglycemic insults acquire permanent aggressive traits of tumor growth, even after a return to euglycemic conditions. Comparative genome-wide mapping of hyperglycemia-specific open chromatin regions and concomitant mRNA expression profiling revealed that neuregulin-1 gene, an established endogenous ligand for the HER3 receptor, is activated through a putative distal enhancer. Our findings highlight the targeted inhibition of NRG1-HER3 pathways as a potential target for the treatment breast cancer patients with associated diabetes Chromatin was extracted from hyperglycemic (HyG) and euglycemic (Control) cancer cells; FAIRE DNA and input DNA from each sample were used to generate libraries for single end sequencing on the the SOLiD 4 HQ system

ORGANISM(S): Mus musculus  

SUBMITTER: Venetia R Sarode   David M Euhus  Thomas Nathan Person  Ralf Kittler  Philipp E Scherer  Jiyoung Park 

PROVIDER: E-GEOD-40949 | ArrayExpress | 2012-09-19



Similar Datasets

| GSE87433 | GEO
2013-08-01 | E-GEOD-44221 | ArrayExpress
2016-07-14 | E-GEOD-75770 | ArrayExpress
2015-04-08 | E-GEOD-54971 | ArrayExpress
2014-06-01 | E-GEOD-57237 | ArrayExpress
2014-06-24 | E-MTAB-2283 | ArrayExpress
2011-01-04 | E-GEOD-23701 | ArrayExpress
2010-11-02 | E-GEOD-23784 | ArrayExpress
| GSE12894 | GEO
2012-09-01 | E-GEOD-37009 | ArrayExpress