Genomics

Dataset Information

296

The Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer


ABSTRACT: Poor outcomes in diabetic patients are observed across a range of human tumors, suggesting that cancer cells develop unique characteristics under diabetic conditions. Cancer cells exposed to hyperglycemic insults acquire permanent aggressive traits of tumor growth, even after a return to euglycemic conditions. Comparative genome-wide mapping of hyperglycemia-specific open chromatin regions and concomitant mRNA expression profiling revealed that neuregulin-1 gene, an established endogenous ligand for the HER3 receptor, is activated through a putative distal enhancer. Our findings highlight the targeted inhibition of NRG1-HER3 pathways as a potential target for the treatment breast cancer patients with associated diabetes Chromatin was extracted from hyperglycemic (HyG) and euglycemic (Control) cancer cells; FAIRE DNA and input DNA from each sample were used to generate libraries for single end sequencing on the the SOLiD 4 HQ system

ORGANISM(S): Mus musculus  

SUBMITTER: Venetia R Sarode   David M Euhus  Thomas Nathan Person  Ralf Kittler  Philipp E Scherer  Jiyoung Park 

PROVIDER: E-GEOD-40949 | ArrayExpress | 2012-09-19

SECONDARY ACCESSION(S): GSE40949SRP015786PRJNA175424

REPOSITORIES: GEO, ArrayExpress, ENA

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