Transcriptomics

Dataset Information

3

Gene expression profiling of Nodal versus Activin-derived endoderm from mouse ES cells


ABSTRACT: To explore the molecular basis of functional differences observed between Nodal versus Activin-derived endoderm, we compared their respective gene expression profiles. Sox17-GFP mouse ES cells were differentiated in the presence of Nodal or Activin for 7 days, after which GFP(+) cells were purified by FACs. Undifferentiated ES cells were also included for comparison as a control. Results indicate that the two endoderm populations are nearly identical at the level of global transcription. Subtle differences suggest a difference in the degree of endoderm progression. Total RNA obtained from SOX17-GFP (+) mouse ES cells, Sox17-GFP treated with Nodal, Sox17-GFP treated with Activin. Two replicates for each sample; Sample data table contains average values of two replicates. The non_normalized.txt file contains individual signal values for each replicate.

ORGANISM(S): Mus musculus  

SUBMITTER: Alice E Chen   Douglas A Melton 

PROVIDER: E-GEOD-41086 | ArrayExpress | 2013-01-01

SECONDARY ACCESSION(S): GSE41086PRJNA175712

REPOSITORIES: GEO, ArrayExpress

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