Transcriptomics

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Transcription profiling of human myelomonocytic leukemia THP-1 cell model treated with ionizing radiation


ABSTRACT: Ionizing radiation (IR) is associated with thrombotic vascular occlusion. Thrombosis in malignancy predicts a poor clinical outcome. Tissue factor (TF) is the initiator of the extrinsic co-agulation system and induces thrombus formation. Our study examined whether IR induced TF expression and procoagulability in the myelomonocytic leukemia THP-1 cell model. We further investigated coordinated gene alterations associated with TF upregulation and IR-induced thrombogenicity. Gene expression profiling revealed IR to increase the expression of inflammatory and apoptosis-related pathways, contributing to TF upregulation and increased TF procoagulability on day 7 post IR. The upregulation of these pathways together with TF upregulation contributed to the increased thrombogenic potential of tissues post application of IR. Experiment Overall Design: THP-1 cells were harvested on day 3 (1 sample) and day 7 (3 samples) post irradiation. For each time point untreated control samples were run.

ORGANISM(S): Homo sapiens  

DISEASE(S): Myelomonocytic Leukemia,Normal

SUBMITTER: Henning Witt   

PROVIDER: E-GEOD-4110 | ArrayExpress | 2012-02-21

SECONDARY ACCESSION(S): GDS1604GSE4110PRJNA94931

REPOSITORIES: GEO, ArrayExpress

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