Transcriptomics

Dataset Information

6

Molecular Characterization of Basal-like and Non-Basal-like Triple-Negative Breast Cancers


ABSTRACT: Triple-negative (TN) and Basal-like (BL) breast cancer definitions have been used interchangeably to identify breast cancers that lack expression of the hormonal receptors (HR) and overexpression and/or amplification of HER2. However, both classifications when compared to each other, show substantial discordance rates. Here, we molecularly characterize TN tumors, and Basal-like tumors, and compare and contrast the results in terms of common patterns and distinct patterns for each. In total, when testing 412 TN and 473 Basal-like tumors, 21.4% and 31.5% were identified as non-Basal-like and non-TN, respectively. TN tumors identified as Luminal or HER2-enriched showed undistinguishable overall gene expression profiles when compared versus Luminal or HER2-enriched tumors that were not TN. Similar findings were observed within Basal-like tumors regardless of the TN status. Interestingly, most TN tumors identified as HER2-enriched showed low HER2 expression and lack of HER2 amplification despite the similar overall gene expression profiles to HER2-E tumors that were not TN. Lastly, additional genomic classifications are examined within TN and Basal-like cancers, most of which are largely concordant with tumor intrinsic subtype. These results suggest that future clinical trials focused on TN disease should consider stratifying patients based on Basal-like versus non-Basal-like gene expression profiles as this appears to be the main biological difference seen within TN breast cancer patients. reference x sample

ORGANISM(S): Homo sapiens  

SUBMITTER: Charles Perou   Aleix Prat  Charles M Perou 

PROVIDER: E-GEOD-41119 | ArrayExpress | 2014-07-29

SECONDARY ACCESSION(S): GSE41119PRJNA256987

REPOSITORIES: GEO, ArrayExpress

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Publications

Molecular characterization of basal-like and non-basal-like triple-negative breast cancer.

Prat Aleix A   Adamo Barbara B   Cheang Maggie C U MC   Anders Carey K CK   Carey Lisa A LA   Perou Charles M CM  

The Oncologist 20130212 2


Triple-negative (TN) and basal-like (BL) breast cancer definitions have been used interchangeably to identify breast cancers that lack expression of the hormone receptors and overexpression and/or amplification of HER2. However, both classifications show substantial discordance rates when compared to each other. Here, we molecularly characterize TN tumors and BL tumors, comparing and contrasting the results in terms of common patterns and distinct patterns for each. In total, when testing 412 TN  ...[more]

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