Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA176028PRJNA176031PRJNA176030
ORGANISM(S): Mus musculus
SUBMITTER: Mareike Albert Sandra U Schmitz Sandra Ursula Schmitz
PROVIDER: E-GEOD-41172 | ArrayExpress | 2013-04-26
SECONDARY ACCESSION(S): SRP015906GSE41172PRJNA176031
REPOSITORIES: GEO, ArrayExpress, ENA
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E-GEOD-41172.idf.txt | Idf | |||
E-GEOD-41172.processed.1.zip | Processed | |||
E-GEOD-41172.processed.2.zip | Processed | |||
E-GEOD-41172.processed.3.zip | Processed | |||
E-GEOD-41172.processed.4.zip | Processed |
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PLoS genetics 20130418 4
Embryonic development is tightly regulated by transcription factors and chromatin-associated proteins. H3K4me3 is associated with active transcription and H3K27me3 with gene repression, while the combination of both keeps genes required for development in a plastic state. Here we show that deletion of the H3K4me2/3 histone demethylase Jarid1b (Kdm5b/Plu1) results in major neonatal lethality due to respiratory failure. Jarid1b knockout embryos have several neural defects including disorganized cr ...[more]