Genomics,Multiomics

Dataset Information

3

Expression data from colorectal cancer patients


ABSTRACT: The study consist of patients who presented at Memorial Sloan-Kettering Cancer Center with a colonic neoplasm between 1992 and 2004. Biological specimens used in this study include primary colon adenocarcinomas, adenomas, metastasis and corresponding normal mucosae. 390 expression arrays

OTHER RELATED OMICS DATASETS IN: PRJNA176361PRJNA282808

ORGANISM(S): Homo sapiens  

TISSUE(S): Microadenoma, Normal Lung, Normal Colon, Lung Metastasis, Primary Tumor, Liver Metastasis, Normal Liver, Polyp, High Grade, Polyp

SUBMITTER: Francis Barany   Manny D Bacolod  Sarah F Giardina  Hanna Pincas  Or Zuk  Daniel A Notterman  Philip B Paty  Michal Sheffer  William L Gerald  Eytan Domany 

PROVIDER: E-GEOD-41258 | ArrayExpress | 2012-10-02

SECONDARY ACCESSION(S): GSE41258PRJNA176361

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-41258.README.txt Txt
E-GEOD-41258.additional.1.zip Other
E-GEOD-41258.idf.txt Idf
E-GEOD-41258.processed.1.zip Processed
E-GEOD-41258.raw.1.zip Raw
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Publications

Association of survival and disease progression with chromosomal instability: a genomic exploration of colorectal cancer.

Sheffer Michal M   Bacolod Manny D MD   Zuk Or O   Giardina Sarah F SF   Pincas Hanna H   Barany Francis F   Paty Philip B PB   Gerald William L WL   Notterman Daniel A DA   Domany Eytan E  

Proceedings of the National Academy of Sciences of the United States of America 20090409 17


During disease progression the cells that comprise solid malignancies undergo significant changes in gene copy number and chromosome structure. Colorectal cancer provides an excellent model to study this process. To indentify and characterize chromosomal abnormalities in colorectal cancer, we performed a statistical analysis of 299 expression and 130 SNP arrays profiled at different stages of the disease, including normal tissue, adenoma, stages 1-4 adenocarcinoma, and metastasis. We identified  ...[more]

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