Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA94991
INSTRUMENT(S): 418 [Affymetrix]
ORGANISM(S): Mus Musculus
SUBMITTER: Irving L. Weissman
PROVIDER: E-GEOD-4142 | ArrayExpress | 2007-12-15
REPOSITORIES: ArrayExpress
Luckey Chance John CJ Bhattacharya Deepta D Goldrath Ananda W AW Weissman Irving L IL Benoist Christophe C Mathis Diane D
Proceedings of the National Academy of Sciences of the United States of America 20060221 9
The only cells of the hematopoietic system that undergo self-renewal for the lifetime of the organism are long-term hematopoietic stem cells and memory T and B cells. To determine whether there is a shared transcriptional program among these self-renewing populations, we first compared the gene-expression profiles of naïve, effector and memory CD8(+) T cells with those of long-term hematopoietic stem cells, short-term hematopoietic stem cells, and lineage-committed progenitors. Transcripts augme ...[more]