Transcriptomics,Multiomics

Dataset Information

4

Transcription profiling of mouse naive B cells vs. antigen-specific plasma, germinal center, and memory B cells after immunization with the T-dependent antigen, NP-CGG, in order to generate a transcriptional profile of self-renewal within the hematopoietic system


ABSTRACT: In order to better understand the factors that regulate B cell differentiation upon exposure to antigen, we compares global gene expression profiles from naive B cells with antigen-specific plasma, germinal center, and memory B cells after immunization with the T-dependent antigen, NP-CGG. The memory B cell-enriched transcripts were then compared with memory T cell-enriched and hematopoietic stem cell-enriched transcripts in order to generate a transcriptional profile of self-renewal within the hematopoietic system.

OTHER RELATED OMICS DATASETS IN: PRJNA94991

INSTRUMENT(S): 418 [Affymetrix]

ORGANISM(S): Mus Musculus

SUBMITTER: Irving L. Weissman  

PROVIDER: E-GEOD-4142 | ArrayExpress | 2007-12-15

REPOSITORIES: ArrayExpress

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Publications

Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells.

Luckey Chance John CJ   Bhattacharya Deepta D   Goldrath Ananda W AW   Weissman Irving L IL   Benoist Christophe C   Mathis Diane D  

Proceedings of the National Academy of Sciences of the United States of America 20060221 9


The only cells of the hematopoietic system that undergo self-renewal for the lifetime of the organism are long-term hematopoietic stem cells and memory T and B cells. To determine whether there is a shared transcriptional program among these self-renewing populations, we first compared the gene-expression profiles of naïve, effector and memory CD8(+) T cells with those of long-term hematopoietic stem cells, short-term hematopoietic stem cells, and lineage-committed progenitors. Transcripts augme  ...[more]

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