Transcriptomics

Dataset Information

6

Toll-like receptor 7 is a primary sensor of malaria infection


ABSTRACT: Microarray profiling of amplified total splenic RNA isolated from TLR9-, TLR7-, UNC93b1- or MYD88- deficient mice or their C57BL/6 controls 24h after mock infection or infection with Plasmodium chabaudi. 4 independent replicates collected from each genotype/infection group, RNA isolated and amplified from whole spleen. Hybridized as a one color experiment.

ORGANISM(S): Mus musculus  

SUBMITTER: Charlie Kim   Alyssa Baccarella  Charles C Kim  Eunice Chen  Mary F Fontana 

PROVIDER: E-GEOD-41496 | ArrayExpress | 2013-09-21

SECONDARY ACCESSION(S): GSE41496PRJNA177224

REPOSITORIES: GEO, ArrayExpress

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Publications

Toll-like receptor 7 mediates early innate immune responses to malaria.

Baccarella Alyssa A   Fontana Mary F MF   Chen Eunice C EC   Kim Charles C CC  

Infection and immunity 20130916 12


Innate immune recognition of malaria parasites is the critical first step in the development of the host response. At present, Toll-like receptor 9 (TLR9) is thought to play a central role in sensing malaria infection. However, we and others have observed that Tlr9(-/-) mice, in contrast to mice deficient in the downstream adaptor, Myeloid differentiation primary response gene 88 (MYD88), exhibit few deficiencies in immune function during early infection with the malaria parasite Plasmodium chab  ...[more]

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