Dataset Information


FOXO3 in control of circadian rhythms via direct regulation of Clock

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus  

SUBMITTER: Marian Groot Koerkamp  

PROVIDER: E-GEOD-41566 | ArrayExpress | 2014-06-03



altmetric image


Insulin-FOXO3 signaling modulates circadian rhythms via regulation of clock transcription.

Chaves Inês I   van der Horst Gijsbertus T J GT   Schellevis Raymond R   Nijman Romana M RM   Koerkamp Marian Groot MG   Holstege Frank C P FC   Smidt Marten P MP   Hoekman Marco F M MF  

Current biology : CB 20140522 11

Circadian rhythms are responsive to external and internal cues, light and metabolism being among the most important. In mammals, the light signal is sensed by the retina and transmitted to the suprachiasmatic nucleus (SCN) master clock [1], where it is integrated into the molecular oscillator via regulation of clock gene transcription. The SCN synchronizes peripheral oscillators, an effect that can be overruled by incoming metabolic signals [2]. As a consequence, peripheral oscillators can be un  ...[more]

Similar Datasets

2014-06-03 | E-GEOD-41555 | ArrayExpress
2014-06-03 | E-GEOD-41554 | ArrayExpress
2016-09-01 | E-GEOD-66404 | ArrayExpress
2014-08-09 | E-GEOD-60137 | ArrayExpress
2012-09-19 | E-GEOD-37052 | ArrayExpress
2016-01-20 | E-MTAB-3763 | ArrayExpress
2012-09-19 | E-GEOD-37051 | ArrayExpress
2014-10-06 | E-GEOD-53046 | ArrayExpress
2015-04-08 | E-GEOD-64503 | ArrayExpress
2015-07-23 | E-GEOD-70481 | ArrayExpress