Dataset Information


MicroRNA expression profile of platelets in sickle cell disease

ABSTRACT: Circulating platelets from Sickle cell disease (SCD) patients express distinct gene expression patterns that regulate function. The objective of this study is to identify a role of post-transcriptional regulation of the platelet transcriptional signaling by microRNAs. Comparison of microRNA expression in platelets from SCD patients and control subjects, from 2 cohorts-University of Pittsburgh and National Institutes of Health.

ORGANISM(S): Homo sapiens  

SUBMITTER: Shilpa Jain   Naftali Kaminski  Mark T Gladwin 

PROVIDER: E-GEOD-41574 | ArrayExpress | 2013-06-20



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BACKGROUND:Increased platelet activation in sickle cell disease (SCD) contributes to a state of hypercoagulability and confers a risk of thromboembolic complications. The role for post-transcriptional regulation of the platelet transcriptome by microRNAs (miRNAs) in SCD has not been previously explored. This is the first study to determine whether platelets from SCD exhibit an altered miRNA expression profile. METHODS AND FINDINGS:We analyzed the expression of miRNAs isolated from platelets from  ...[more]

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