Transcriptomics,Genomics

Dataset Information

8

Methylomic analysis identifies the involvement of migration and adhesion genes in the ageing of primary haematopoietic stem cells


ABSTRACT: we utilize Nano-MeDIP-seq for the analysis of the LT-HSC methylome and, for the first time, simultaneously interrogate the methylome and transcriptome of a homogeneous population of primary murine HSCs, in order to define the underlying causes of changes in HSC functionality during normal ageing. We isolated and phenotyped primary LT-HSCs from young, middle-aged and old mice and subjected them to comprehensive methylome (MeDIP-seq) and transcriptome (RNA-seq) analysis.

ORGANISM(S): Mus musculus  

SUBMITTER: Stephan Beck   Warren Emmett  Daniel Pearce  Tomas Adejumo  Tiffany Morris  Gareth Wilson  Dominique Bonnet  Gareth A Wilson  Oluwatosin Taiwo 

PROVIDER: E-GEOD-41658 | ArrayExpress | 2013-11-01

SECONDARY ACCESSION(S): SRP016510GSE41658PRJNA177844

REPOSITORIES: GEO, ArrayExpress, ENA

Dataset's files

Source:
Action DRS
E-GEOD-41658.idf.txt Idf
E-GEOD-41658.processed.1.zip Processed
E-GEOD-41658.processed.2.zip Processed
E-GEOD-41658.sdrf.txt Txt
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