Transcriptomics

Dataset Information

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Transcription profiling by array of human right ventricle endomyocardial biopsies from patients with inflammatory cardiomyopathy


ABSTRACT: Since targeting of specific pathogenic pathways may be more efficient than current unspecific heart failure treatment, we obtained genomewide expression profiles of a DCM subtype characterized by cardiac inflammation (DCMi) in association with parvovirus B19. This study was entirely based on RNA isolated from endomyocardial biopsies so far only rarely used for genomic expression profiling. Experiment Overall Design: Samples derived from 8 DCMi and 4 healthy control patients were hybridised onto Affymetrix U133 Plus arrays.

ORGANISM(S): Homo sapiens  

SUBMITTER: Henning Witt   

PROVIDER: E-GEOD-4172 | ArrayExpress | 2007-10-02

SECONDARY ACCESSION(S): GSE4172GDS2154PRJNA95089

REPOSITORIES: GEO, ArrayExpress

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Publications

Genomic expression profiling of human inflammatory cardiomyopathy (DCMi) suggests novel therapeutic targets.

Wittchen F F   Suckau L L   Witt H H   Skurk C C   Lassner D D   Fechner H H   Sipo I I   Ungethüm U U   Ruiz P P   Pauschinger M M   Tschope C C   Rauch U U   Kühl U U   Schultheiss H-P HP   Poller W W  

Journal of molecular medicine (Berlin, Germany) 20061115 3


The clinical phenotype of human dilated cardiomyopathy (DCM) encompasses a broad spectrum of etiologically distinct disorders. As targeting of etiology-related pathogenic pathways may be more efficient than current standard heart failure treatment, we obtained the genomic expression profile of a DCM subtype characterized by cardiac inflammation to identify possible new therapeutic targets in humans. In this inflammatory cardiomyopathy (DCMi), a distinctive cardiac expression pattern not describe  ...[more]

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