Transcriptomics

Dataset Information

110

Genome-wide transcriptional analysis of PE-2 strain of Saccharomyces cerevisiae


ABSTRACT: In this study we investigate the molecular physiology of the main S. cerevisiae commercial strain (PE-2) used on Brazilian bioethanol process under two distinct conditions: typical (TF) and flocculated (co-aggregated - FL) fermentation. Transcriptional machinery of PE-2 was assessed by high throughput sequencing-based methods (RNA-seq) during industrial fed-batch fermentations. Data from comparative analysis revealed distinct transcriptional profiles among conditions, characterized mainly by a deep gene repression on FL process. We investigated the transcriptional changes in S. cerevisiae PE-2 strain under industrial fermentation conditions using RNA-seq protocols. We analyzed 13 fermentation time-points where 6 time-points on typical fermentation conditions (TF) and 7 time-points on flocculate conditions(FL). The raw data have been submitted to SRA as SRP014755

ORGANISM(S): Saccharomyces cerevisiae  

SUBMITTER: Osmar V Carvalho-Netto  Osmar Netto   Juan L Argueso   Luige A Calderón   Paulo J Teixeira   Marcelo F Carazzolle   Gonçalo A Pereira   Luciana S Mofatto   Melline F Noronha   Piotr A Mieczkowski    

PROVIDER: E-GEOD-41834 | ArrayExpress | 2015-02-07

SECONDARY ACCESSION(S): SRP014755GSE41834PRJNA178278

REPOSITORIES: GEO, ArrayExpress, ENA

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Publications

Saccharomyces cerevisiae transcriptional reprograming due to bacterial contamination during industrial scale bioethanol production.

Carvalho-Netto Osmar V OV   Carazzolle Marcelo F MF   Mofatto Luciana S LS   Teixeira Paulo J P L PJ   Noronha Melline F MF   Calderón Luige A L LA   Mieczkowski Piotr A PA   Argueso Juan Lucas JL   Pereira Gonçalo A G GA  

Microbial cell factories 20150130


The bioethanol production system used in Brazil is based on the fermentation of sucrose from sugarcane feedstock by highly adapted strains of the yeast Saccharomyces cerevisiae. Bacterial contaminants present in the distillery environment often produce yeast-bacteria cellular co-aggregation particles that resemble yeast-yeast cell adhesion (flocculation). The formation of such particles is undesirable because it slows the fermentation kinetics and reduces the overall bioethanol yield.In this stu  ...[more]

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