Transcriptomics

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Longitudinal expression data from CD4+ T cells responding to LCMV-Armstrong or LCMV-Clone 13


ABSTRACT: During acute viral infections, naïve CD4+ T cells differentiate into effector CD4+ T cells and, after viral control, into memory CD4+ T cells. Memory CD4+ T cells are highly functional, proliferate rapidly upon reinfection and persist long-term without antigen. In contrast, during chronic infections, CD4+ T cells become less functional. To compare the development of functional memory T cells with poorly functional T cells from chronic viral infection, we generated longitudinal transcriptional profiles for each. Naive CD44Lo CD4+ T cells were isolated and sorted from uninfected C57BL/6 mice and H2-IAb GP66-specific CD4+ T cells were sorted using MHC-II tetramers at d6, 8, 15, and 30 p.i. with either LCMV Arm or LCMV clone 13. RNA from these CD4+ T cells was processed, amplified, labeled, and hybridized to Affymetrix GeneChip MoGene 1.0 st microarrays.

ORGANISM(S): Mus musculus  

SUBMITTER: E J Wherry   E John Wherry  Alison Crawford  Jill Angelosanto 

PROVIDER: E-GEOD-41866 | ArrayExpress | 2014-10-24

SECONDARY ACCESSION(S): GSE41866PRJNA178354

REPOSITORIES: GEO, ArrayExpress

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