Transcriptomics

Dataset Information

5

Pd-1 High and Intermediate CD8+ T cells


ABSTRACT: During acute viral infections, naïve CD8+ T cells differentiate into effector CD8+ T cells and, after viral control, into memory CD8+ T cells. Memory CD8+ T cells are highly functional, proliferate rapidly upon reinfection and persist long-term without antigen. In contrast, during chronic infections, CD8+ T cells become “exhausted” and have poor effector function, express multiple inhibitory receptors, possess low proliferative capacity, and cannot persist without antigen. Exhuasted CD8+ T cells can be further segregated by their expression of the inhibitory cell surface receptor PD-1. We performed transcriptional profiling on both PD-1 High and PD-1 Intermediate H2-Db GP33-specific CD8+ T cells. H2-Db GP33-specific CD8+ T cells were sorted from C57BL/6 mice 30 days p.i. with LCMV clone 13. These cells were then segregated by their expression of the inhibitory cell surface receptor PD-1 into PD-1 High and PD-1 Intermediate subpopulations. We performed transcriptional profiling on these subpopulations.

ORGANISM(S): Mus musculus  

SUBMITTER: E J Wherry   E John Wherry  Alison Crawford  Jill Angelosanto 

PROVIDER: E-GEOD-41869 | ArrayExpress | 2014-10-24

SECONDARY ACCESSION(S): GSE41869PRJNA178356

REPOSITORIES: GEO, ArrayExpress

Dataset's files

Source:
Action DRS
E-GEOD-41869.idf.txt Idf
E-GEOD-41869.processed.1.zip Processed
E-GEOD-41869.raw.1.zip Raw
E-GEOD-41869.sdrf.txt Txt
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