Dataset Information


Immune and tumor cell gene expression from node positive and node negative breast cancers' primary tumor, lymph nodes and peripheral blood

ABSTRACT: Analysis of purified immune and breast tumor cells from three major compartments where cancer and immune cells interact: primary tumor, tumor draining lymph nodes (tumor invaded or tumor free), and peripheral blood. The results suggests that node-positive patients’ immune regulation and functionality is down-regulated compared to node-negative patients. CD45+ Immune and ESA+ tumor cells were purified from breast cancer patients' primary tumor, tumor-draining lymph node, and peripheral blood (ficoll) and placed onto Agilent microarrays using the dye-swap method. A universal human reference was used as a reference for the patient samples.

ORGANISM(S): Homo sapiens  

SUBMITTER: Hongxiang Yu   Diana L Simons  Peter P Lee 

PROVIDER: E-GEOD-41986 | ArrayExpress | 2013-01-11



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Altered local and systemic immune profiles underlie lymph node metastasis in breast cancer patients.

Zuckerman Neta S NS   Yu Hongxiang H   Simons Diana L DL   Bhattacharya Nupur N   Carcamo-Cavazos Valeria V   Yan Ning N   Dirbas Frederick M FM   Johnson Denise L DL   Schwartz Erich J EJ   Lee Peter P PP  

International journal of cancer 20121126 11

Cancer-mediated immune dysfunction contributes to tumor progression and correlates with patient outcome. Metastasis to tumor draining lymph nodes (TDLNs) is an important step in breast cancer progression and is used to predict patient outcome and survival. Although lymph nodes are important immune organs, the role of immune cells in TDLNs has not been thoroughly investigated. We hypothesized that the host immune response in node negative (NN) patients is more intact and thereby can resist tumor  ...[more]

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