Transcriptomics

Dataset Information

3

Immune and tumor cell gene expression from node positive and node negative breast cancers' primary tumor, lymph nodes and peripheral blood


ABSTRACT: Analysis of purified immune and breast tumor cells from three major compartments where cancer and immune cells interact: primary tumor, tumor draining lymph nodes (tumor invaded or tumor free), and peripheral blood. The results suggests that node-positive patients’ immune regulation and functionality is down-regulated compared to node-negative patients. CD45+ Immune and ESA+ tumor cells were purified from breast cancer patients' primary tumor, tumor-draining lymph node, and peripheral blood (ficoll) and placed onto Agilent microarrays using the dye-swap method. A universal human reference was used as a reference for the patient samples.

ORGANISM(S): Homo sapiens  

SUBMITTER: Hongxiang Yu   Diana L Simons  Peter P Lee 

PROVIDER: E-GEOD-41986 | ArrayExpress | 2013-01-11

SECONDARY ACCESSION(S): GSE41986PRJNA178662

REPOSITORIES: GEO, ArrayExpress

altmetric image

Publications

Altered local and systemic immune profiles underlie lymph node metastasis in breast cancer patients.

Zuckerman Neta S NS   Yu Hongxiang H   Simons Diana L DL   Bhattacharya Nupur N   Carcamo-Cavazos Valeria V   Yan Ning N   Dirbas Frederick M FM   Johnson Denise L DL   Schwartz Erich J EJ   Lee Peter P PP  

International journal of cancer 20121126 11


Cancer-mediated immune dysfunction contributes to tumor progression and correlates with patient outcome. Metastasis to tumor draining lymph nodes (TDLNs) is an important step in breast cancer progression and is used to predict patient outcome and survival. Although lymph nodes are important immune organs, the role of immune cells in TDLNs has not been thoroughly investigated. We hypothesized that the host immune response in node negative (NN) patients is more intact and thereby can resist tumor  ...[more]

Publication: 1/2

Similar Datasets

| GSE81146 | GEO
2013-08-01 | E-GEOD-39945 | ArrayExpress
| GSE113250 | GEO
2018-10-26 | PXD005539 | Pride
2012-10-23 | E-GEOD-41736 | ArrayExpress
2012-03-31 | E-GEOD-36306 | ArrayExpress
2015-05-18 | E-GEOD-51021 | ArrayExpress
| GSE73728 | GEO
2011-02-04 | E-GEOD-23177 | ArrayExpress
| GSE23177 | GEO